Please take a look at the
Frequently Asked Questions
and
Tutorial
if you are new to FluSurver. You could also look at this
NA drug susceptibility example analysis walkthrough starting from
GISAID
and the
GISAID
access summary poster
Paste your protein or nucleotide FASTA sequence(s) into the text area below.
(
Sample FASTA sequences: 2009 H1N1 NA and HA
)
OR
upload your protein or nucleotide sequences in a FASTA file
The server can
automatically
determine the type of input (either protein or nucleotide) and the closest reference sequence among current
vaccine strains to compare. Also mixtures of genes/proteins (e.g. HA and NA or all genes of the same patient) can be provided as input.
To compare with more remotely related sequences/strains, it is possible to select a specific reference strain by choosing below.
Compare with:
Automatic detection of closest reference (larger selection of strains, not always full genomes)
Automatic detection of closest reference (among current vaccine strains, full genomes)
A/BrevigMission/1/1918(H1N1) - 1918 pandemic - Spanish flu
A/WSN/1933(H1N1)
A/NewJersey/11/1976(H1N1) - 1976 Swine flu
A/Brisbane/59/2007(H1N1) - seasonal H1N1 - old H1 vaccine
A/California/07/2009(H1N1) - 2009 pandemic - seasonal - old H1 vaccine
A/Michigan/45/2015(H1N1) - evolved from 2009 pandemic - seasonal - old H1 vaccine (E3)
A/Brisbane/02/2018(H1N1) - evolved from 2009 pandemic - seasonal - old H1 vaccine (E3)
A/GuangdongMaonan/SWL1536/2019(H1N1) - evolved from 2009 pandemic - seasonal - old H1 vaccine (E8)
A/Hawaii/70/2019(H1N1) - seasonal - old H1 vaccine - cell-derived (C1)
A/Victoria/2570/2019(H1N1) - evolved from 2009 pandemic - seasonal - old H1 vaccine (E4)
A/Wisconsin/588/2019(H1N1) - seasonal - old H1 vaccine - cell-derived (C1)
A/Sydney/5/2021(H1N1) - evolved from 2009 pandemic - seasonal - old H1 vaccine (E3/E1)
A/Sydney/5/2021(H1N1) - seasonal - old H1 vaccine - cell-derived (C2)
A/Victoria/4897/2022(H1N1) - evolved from 2009 pandemic - seasonal - current H1 vaccine (E3/E1)
A/Wisconsin/67/2022(H1N1) - seasonal - current H1 vaccine - cell-derived (S1)
A/Minnesota/19/2011(H1N2) - swine-origin - cell-derived (M1M2)
A/Singapore/1/1957(H2N2) - 1957/58 pandemic - Asian flu
A/Canada/720/2005(H2N2)
A/HongKong/1/1968(H3N2) - 1968/69 pandemic - Hong Kong flu
A/Wisconsin/67/2005(H3N2) - seasonal - old H3 vaccine
A/Brisbane/10/2007(H3N2) - seasonal - old H3 vaccine
A/Perth/16/2009(H3N2) - seasonal - old H3 vaccine
A/Victoria/361/2011(H3N2) - seasonal - old H3 vaccine
A/Texas/50/2012(H3N2) - seasonal - old H3 vaccine - egg-derived (E5)
A/Texas/50/2012(H3N2) - seasonal - old H3 vaccine - cell-derived (M1/C2)
A/Switzerland/9715293/2013(H3N2) - seasonal - old H3 vaccine - egg-derived (E4/E2)
A/Switzerland/9715293/2013(H3N2) - seasonal - old H3 vaccine - cell-derived (S1S2/S2)
A/HongKong/4801/2014(H3N2) - seasonal - old H3 vaccine - egg-derived (E5/E2)
A/HongKong/4801/2014(H3N2) - seasonal - old H3 vaccine - cell-derived (C4/S2)
A/Singapore/INFIMH-16-0019/2016(H3N2) - seasonal - old H3 vaccine - egg-derived (E5/E1)
A/Singapore/INFIMH-16-0019/2016(H3N2) - seasonal - old H3 vaccine - cell-derived (C1S3/S1)
A/Kansas/14/2017(H3N2) - seasonal - old H3 vaccine - egg-derived (E5)
A/Kansas/14/2017(H3N2) - seasonal - old H3 vaccine - cell-derived (S1)
A/Switzerland/8060/2017(H3N2) - seasonal - old H3 vaccine - egg-derived (E5/E1)
A/Switzerland/8060/2017(H3N2) - seasonal - old H3 vaccine - cell-derived (S2/S1)
A/HongKong/2671/2019(H3N2) - seasonal - old H3 vaccine - egg-derived (E7/E2)
A/HongKong/45/2019(H3N2) - seasonal - old H3 vaccine - cell-derived (S4)
A/SouthAustralia/34/2019(H3N2) - seasonal - old H3 vaccine - egg-derived (E5)
A/SouthAustralia/34/2019(H3N2) - seasonal - old H3 vaccine - cell-derived (S2)
A/Darwin/6/2021(H3N2) - seasonal - old H3 vaccine - cell-derived (S2/S2)
A/Darwin/9/2021(H3N2) - seasonal - old H3 vaccine - egg-derived (E3/E2)
A/Massachusetts/18/2022(H3N2) - seasonal - old H3 vaccine - cell-derived (S3)
A/Thailand/8/2022(H3N2) - seasonal - old H3 vaccine - egg-derived (E3)
A/Croatia/10136RV/2023(H3N2) - seasonal - current H3 vaccine - egg-derived (E3/E1)
A/DistrictOfColumbia/27/2023(H3N2) - seasonal - current H3 vaccine - cell-derived (S1)
A/Indiana/10/2011(H3N2v) - swine-origin H3N2 with M segment from human H1N1pdm - vaccine candidate
A/Equine/Miami/1/1963(H3N8)
A/Equine/Sussex/1/1989(H3N8)
A/Equine/Kentucky/1/1992(H3N8)
A/Duck/HongKong/24/1976(H4N2)
A/AmericanWigeon/SouthCarolina/22-000345-001/2021(H5N1) - clade 2.3.4.4b avian-origin H5N1 - vaccine candidate
A/Chicken/Ghana/AVL-76321VIR7050-39/2021(H5N1) - clade 2.3.4.4b avian-origin H5N1 - vaccine candidate
A/Dairycow/Texas/24-008749-002-V/2024(H5N1) - clade 2.3.4.4b H5N1
A/Duck/EasternChina/108/2008(H5N1)
A/Duck/Vietnam/NCVD-1584/2012(H5N1) - clade 2.3.2.1c avian-origin H5N1
A/Goose/Guangdong/1/1996(H5N1)
A/VietNam/1203/2004(H5N1) - clade 1 avian-origin H5N1 - vaccine candidate
A/Anhui/1/2005(H5N1)
A/Indonesia/5/2005(H5N1) - clade 2.1.3.2 avian-origin H5N1 - vaccine candidate
A/Egypt/1394-NAMRU3/2007(H5N1) - clade 2.2.1v - vaccine candidate
A/Egypt/2321-NAMRU3/2007(H5N1) - clade 2.2.1p - old poultry vaccine strain
A/Hubei/1/2010(H5N1) - clade 2.3.2.1 avian-origin H5N1 - vaccine candidate
A/Cambodia/NPH230032/2023(H5N1) - clade 2.3.2.1c avian-origin H5N1
A/Texas/37/2024(H5N1) - clade 2.3.4.4b avian-origin H5N1
A/Chicken/BC/FAV8/2014(H5N2)
A/Sichuan/26221/2014(H5N6) - novel avian flu with rare zoonosis
A/FujianSanyuan/21099/2017(H5N6) - clade 2.3.4.4b - vaccine candidate - cell-derived (C1)
A/Baikalteal/Korea/Donglim3/2014(H5N8) - novel avian flu 2014
A/Gyrfalcon/Washington/41088-6/2014(H5N8) - clade 2.3.4.4c
A/Astrakhan/3212/2020(H5N8) - clade 2.3.4.4b - vaccine candidate - cell-derived (c2)
A/Duck/Taiwan/0526/1972(H6N1)
A/Taiwan/2/2013(H6N1)
A/Canada/RV504/2004(H7N3) - avian flu with rare zoonosis - North American lineage
A/Netherlands/219/2003(H7N7) - avian flu with rare zoonosis - Eurasian lineage
A/PrecursorMix/1/2013(H7N9) - mix of best hit precursors for novel avian-origin flu
A/Shanghai/02/2013(H7N9) - novel avian-origin flu - human representative case (Genbank)
A/Shanghai/2/2013(H7N9) - novel avian-origin flu - human representative case (GISAID)
A/Guangdong/17SF003/2016(H7N9) - novel avian-origin flu - vaccine candidate
A/Turkey/Ontario/6118/1968(H8N4)
A/Chicken/HongKong/G9/1997(H9N2)
A/Duck/HongKong/Y280/1997(H9N2)
A/HongKong/3239/2008(H9N2) - common avian flu with rare zoonosis
A/Quail/HongKong/G1/1997(H9N2)
A/Duck/Guangdong/E1/2012(H10N8)
A/Quail/Italy/1117/1965(H10N8)
A/Duck/Memphis/546/1974(H11N9)
A/Duck/Alberta/60/1976(H12N5)
A/Gull/Maryland/704/1977(H13N6)
A/Mallard/Astrakhan/263/1982(H14N5)
A/Shearwater/Australia/2576/1979(H15N9)
A/Herringgull/NewJersey/780/1986(H16N3)
B/Florida/4/2006 - seasonal flu B - Yamagata lineage - old B vaccine
B/Brisbane/60/2008 - seasonal flu B - Victoria lineage - old B vaccine
B/Massachusetts/02/2012 - seasonal flu B - Yamagata lineage - old B vaccine
B/Phuket/3073/2013 - seasonal flu B - Yamagata lineage - current B vaccine (E4/E2)
B/Phuket/3073/2013 - seasonal flu B - Yamagata lineage - current B vaccine - cell-derived (C2/C2)
B/Colorado/06/2017 - seasonal flu B - Victoria lineage - old B vaccine (E5)
B/Washington/02/2019 - seasonal flu B - Victoria lineage - old B vaccine (E2)
B/Washington/02/2019 - seasonal flu B - Victoria lineage - old B vaccine - cell-derived (C1)
B/Austria/1359417/2021 - seasonal flu B - Victoria lineage - current B vaccine (E3/E2)
B/Austria/1359417/2021 - seasonal flu B - Victoria lineage - current B vaccine - cell-derived (S1C4)
Additional settings:
ignore low quality bases for nucleotide input (indicated by lower case, except for all lower case sequences)
genotype call for H5N1 2.3.4.4b genomes (user input must be nucleotide sequences and needs to contain exactly all 8 influenza segments)
(estimated time needed: ~2 seconds per sequence in automatic mode)